Post-paraquat era: What is the way out for the pyridine industry?
Recently, the Ministry of Agriculture, the Ministry of Industry and Information Technology, and the General Administration of Quality Supervision, Inspection and Quarantine jointly issued a public notice setting out a clear timetable for the use of paraquat aqueous drugs: since July 1, 2014, registration and production of paraquat aqueous solutions The license will be revoked. On July 1, 2016, the liquid agent will be sold and used domestically. As the largest downstream consumer of pyridine, paraquat's prohibition will have a certain impact on the pyridine industry. After the paraquat era, what will the pyridine industry do?
From September 18th to 19th, at the 2012 pyridine and its derivative market summit hosted by the China National Chemical Information Center in Shanghai, experts in the industry believed that although paraquat water agents are subject to restrictions, other pyridine products will still be available. Broad market prospects. In the future, the industry can focus on the development of alternative formulations of paraquat water solutions or the development of high value-added, highly effective pyridine pesticide products and pharmaceutical products.
Some experts also said that although these areas have a certain market space, but to truly develop, will also face many problems and have a long way to go. What kind of product companies choose, what kind of production scale, etc. need further analysis and investigation.
At the meeting, the reporter learned that paraquat is the second largest herbicide species after glyphosate. At present, 60% to 70% of the world's pyridine is used to produce paraquat, and 60% of the world's demand for paraquat is in China. Therefore, the development of paraquat in our country has a crucial influence on the pyridine industry. However, in recent years, paraquat safety and accidental accidents have occurred frequently, and no drugs can cure them after being taken by mistake. Therefore, the three departments decided to jointly implement the prohibition measures.
Prof. Leng Yang from Shanghai Pesticide Research Institute told the reporter: “Aqueous agent is the only industrialized formulation of paraquat. Therefore, whether it is possible to develop a new alternative formulation of paraquat aqueous solution is related to the fate of paraquat. The possibility of misappropriation or production of drugs by the animals is at the heart of alternative formulation development."
According to the reporter's understanding, paraquat companies and related hospitals are currently making greater efforts to develop safe alternative drug products. Research and development mainly focuses on the preparation of water-soluble adhesives, soluble granules by spray-drying, and soluble granules by extrusion. However, there are still many problems in the implementation of these technologies. For example, in the preparation of water-soluble adhesives, high-viscosity preparations must exhibit better automatic dispersibility in water, and problems such as equipment selection, product packaging design, waste packaging management, etc. must also be considered; spray-drying method can be used to make soluble particles. The agent is faced with the problem of clean production; the technology for making soluble granules by extrusion must also consider the implementation of the mother liquor concentration process and the connection of the granulation process.
Leng Yang emphasized that "the paraquat alternatives have yet to pass through three levels on the road to industrialization and commercialization. The first is product safety evaluation and review, including the safety of the production process and the safety of the use process; the second is the production of products. Economics, which requires that the cost price can not be too high; the third is to pass the user's inertia, in the efficacy, price, use, etc. have to have advantages compared with the raw water agent to meet customer needs."
Prof. Hu Xiaoxing of the Pesticide Technology Center believes that “Although all efforts are being made to improve dosage forms, it is difficult to compete with the original aqueous solution in terms of process, formulation complexity, ease of use, and acceptance of farmers. Paraquat Into the sunset era." He pointed out that the future direction of pyridine should be placed on other high value-added, high-efficiency new pesticides containing pyridine. At present, there are 50 to 60 kinds of pesticide products containing pyridine. Many pyridine-containing pesticides are no longer protected by patents, which also provides facilities for the development of pyridine pesticides.
Yang Weilan, vice president of the Industrial Economics Research Institute of the China National Chemical Information Center, believes that the only way out for the pyridine industry is to intensify the development of new markets, especially the emphasis on the development of high-value-added specialty chemicals for small tonnage, focusing on pyridine in the field of lithium-ion batteries and new materials. application.
“The downstream market of pyridine can also be turned to the field of pharmaceutical applications to produce anti-tumor substances such as imatinib and cardiovascular drugs such as milrinone,†said Tao Jianhong, deputy director of the Southern Medicine Economic Research Institute. She pointed out that in China's "12th five-year plan" for industrial technological innovation, characteristic chemical raw material drugs are listed as the focus of the pharmaceutical manufacturing industry. With the implementation of universal health care, pyridine drugs will have better development space.
At present, many pyridine derivatives in China still need to be imported. It is of utmost importance to develop high value-added pyridine compounds with independent intellectual property rights. Fu Yongkuan, chief engineer of Tangshan Chenhong Industrial Co., Ltd., believes that the market demand for pyridine compounds in China is strong and the import intensity continues. With the continuous development of pyridine derivative products and the expansion of the application range, pyridine products still have a large market potential. In the future, the potential of the pyridine industry market in China will focus on pharmaceuticals and pesticides, especially fluoropyridines used in pesticides, chloropyridines used in the production of high value-added fine chemical products such as spices. To this end, China should speed up the development of pyridine derivatives in science and technology and application areas, accelerate the localization of pyridine derivative production process technology, establish a production system that meets the characteristics of China's market, and truly form and improve technology-production-applications. Green environmental protection chemical industrial chain. The relevant state departments should also guide and support them from the policy aspect.
Lu Xianfeng, deputy chief engineer of China National Chemical Information Center, introduced that the market for pyridine and its downstream derivatives in China is continuously expanding. From 2009 to 2011, the growth rate of pyridine and its derivatives in China exceeded 13%, and China has become an important global production and consumption region for pyridine products. With the global development of pyridine industry, downstream product production and market transfer, the pyridine industry will usher in the era of mergers and reorganizations.
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